HLA-DQB2

Across TCGA pan-cancer cohorts, HLA-DQB2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HLA-DQB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DQB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DQB2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where HLA-DQB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DQB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.888	<.001	11	view →
THCA	Male	III,IV	+3.081	<.001	10	view →
LUSC	Male	II,III,IV	−2.195	<.001	6	view →
BRCA	Female	All	+0.594	.001	4	view →
LUAD	Male	All	−1.483	.010	2	view →
PAAD	Female	All	−1.364	.029	2	view →
KIRP	All	All	+0.943	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HLA-DQB2–KIRC

Open the KIRC breakdown →