HLA-DQB2

Across TCGA pan-cancer cohorts, HLA-DQB2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HLA-DQB2 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DQB2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DQB2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and UVM are the cancer types where HLA-DQB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.428	0.272	<.001	134	view →
KIRC	DFS	Median	III,IV	0.581	0.358	<.001	86	view →
UVM	DFS	Median	All	0.399	0.790	<.001	72	view →
HNSC	DFS	Tertile	All	0.791	0.640	<.001	51	view →
BRCA	DFS	Median	All	0.603	0.465	<.001	50	view →
LGG	OS	Median	All	0.353	0.528	<.001	46	view →
SCLC	DFS	Median	All	0.773	0.464	<.001	36	view →
LUAD	DFS	Quartile	All	0.865	0.720	.001	34	view →
SARC	OS	Quartile	All	0.833	0.639	.001	18	view →
DLBC	OS	Tertile	All	0.709	1.000	.009	15	view →
KIRP	OS	Median	All	0.806	0.554	.005	13	view →
LIHC	OS	Median	All	0.637	0.771	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HLA-DQB2–SKCM (OS)

Open the SKCM breakdown →