HLA-DQB1

Across TCGA patient cohorts, HLA-DQB1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,733 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DQB1-associated genes across cancer lineages are HLA-DQB1-AS1, HLA-DRB1, and HLA-DQA1. Each is linked with HLA-DQB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DQB1-to-partner and partner-to-HLA-DQB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DQB1 versus HLA-DQB1-AS1 in UCEC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB1→partner) and Y-score (partner→HLA-DQB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HLA-DQB1-AS1 →	+1.160	+1.098	<.001	<.001	3	10
COAD	HLA-DRB1 →	+1.044	+1.061	<.001	<.001	3	8
OV	HLA-DQA1 →	+1.245	+0.489	<.001	<.001	3	8
LSCC	HLA-DRB5 →	+1.822	+1.300	<.001	<.001	3	8
GBM	HLA-DPB1 →	+1.386	+1.143	<.001	<.001	3	7
GBM	HLA-DPA1 →	+1.276	+1.030	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,733 associations by consensus.

HLA-DQB1 vs HLA-DQB1-AS1 — UCEC

Explore this scatter interactively →