HLA-DQB1

Across TCGA pan-cancer cohorts, HLA-DQB1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HLA-DQB1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DQB1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DQB1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, UVM, and KIRC are the cancer types where HLA-DQB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.466	0.247	<.001	124	view →
UVM	DFS	Median	All	0.384	0.735	.001	70	view →
KIRC	DFS	Tertile	II,III,IV	0.877	0.741	.002	67	view →
LGG	OS	Median	All	0.730	0.890	<.001	47	view →
CESC	OS	Quartile	All	0.856	0.715	.014	42	view →
LUAD	DFS	Median	All	0.455	0.258	<.001	36	view →
LAML	DFS	Tertile	All	0.370	0.607	.009	30	view →
LIHC	OS	Tertile	III,IV	0.795	0.444	.004	28	view →
KIRP	DFS	Tertile	III,IV	0.410	0.909	.018	19	view →
SCLC	DFS	Median	All	0.939	0.590	.007	18	view →
BRCA	OS	Median	All	0.970	0.954	.017	15	view →
HNSC	DFS	Quartile	III,IV	0.480	0.155	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HLA-DQB1–SKCM (OS)

Open the SKCM breakdown →