HLA-DQB1

Across TCGA pan-cancer cohorts, HLA-DQB1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HLA-DQB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DQB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DQB1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where HLA-DQB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DQB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.760	<.001	12	view →
LUAD	Male	II,III,IV	−1.606	<.001	9	view →
LUSC	Male	II,III,IV	−2.439	<.001	8	view →
THCA	Male	II,III,IV	+2.237	<.001	8	view →
STAD	Female	All	+2.094	<.001	4	view →
LIHC	Female	III,IV	+1.230	.006	4	view →
BRCA	Female	All	+0.607	<.001	4	view →
KICH	All	IV	−1.232	.012	3	view →
KIRP	Male	All	+1.194	.009	2	view →
CHOL	Female	All	+3.209	.040	1	view →
ESCA	Female	All	+1.763	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HLA-DQB1–KIRC

Open the KIRC breakdown →