HLA-DQB1

Across TCGA cell cohorts, HLA-DQB1 RNA expression is significantly associated with the RNA expression of many other genes, with 4,276 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DQB1-associated genes across cancer lineages are HLA-DRB1, HLA-DRB5, and HLA-DRA. Each is linked with HLA-DQB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both HLA-DQB1-to-partner and partner-to-HLA-DQB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DQB1 versus HLA-DRB1 in BLOOD_Myeloma, with a Pearson correlation of 0.91.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB1→partner) and Y-score (partner→HLA-DQB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HLA-DRB1 →	+5.348	+5.057	<.001	<.001	3	16
BLOOD_Myeloma	HLA-DRB5 →	+4.550	+5.057	<.001	<.001	3	13
BLOOD_Myeloma	HLA-DRA →	+5.619	+4.308	<.001	<.001	3	12
BLOOD_Myeloma	CD74 →	+5.111	+4.255	<.001	<.001	3	12
BLOOD_Leukemia	HLA-DMA →	+3.016	+3.740	<.001	<.001	3	10
BLOOD_Leukemia	HLA-DPA1 →	+4.800	+3.904	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,276 associations by consensus.

HLA-DQB1 vs HLA-DRB1 — BLOOD_Myeloma

Explore this scatter interactively →