HLA-DQA2

Across TCGA patient cohorts, HLA-DQA2 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DQA2-associated genes across cancer lineages are MIR4516, TXN2P1, and HACL1. Each is linked with HLA-DQA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DQA2-to-partner and partner-to-HLA-DQA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4516 grouped by HLA-DQA2-low versus HLA-DQA2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQA2→partner) and Y-score (partner→HLA-DQA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4516 →	+0.652	+4.339	<.001	.007	3	2
SKCM	TXN2P1 →	+0.190	+4.095	.002	<.001	3	2
UCEC	HACL1 →	+0.699	+3.584	<.001	.003	3	2
UCEC	LINC02369 →	+0.100	+2.515	.002	.005	3	2
LGG	DEFB106A →	+0.129	+7.977	<.001	.007	3	1
LGG	MTND5P41 →	+0.333	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

MIR4516 by HLA-DQA2 expression — LUSC

Explore this box plot interactively →