HLA-DQA2

Across TCGA pan-cancer cohorts, HLA-DQA2 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated HLA-DQA2 data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DQA2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DQA2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, UVM, and CESC are the cancer types where HLA-DQA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	All	0.485	0.250	<.001	79	view →
UVM	OS	Tertile	All	0.324	0.705	<.001	76	view →
CESC	OS	Median	II,III,IV	0.890	0.750	.017	50	view →
KIRC	DFS	Quartile	II,III,IV	0.668	0.391	<.001	50	view →
HNSC	DFS	Median	All	0.770	0.647	.001	48	view →
ACC	DFS	Tertile	All	0.706	0.217	.003	47	view →
LGG	DFS	Median	All	0.279	0.517	<.001	43	view →
THCA	DFS	Tertile	II,III,IV	0.617	0.968	<.001	33	view →
BRCA	DFS	Median	IV	0.947	0.533	.006	29	view →
LUAD	DFS	Median	III,IV	0.604	0.368	.003	24	view →
CHOL	DFS	Median	II,III,IV	0.558	0.109	.006	20	view →
MESO	DFS	Tertile	All	0.444	0.269	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

HLA-DQA2–SKCM (OS)

Open the SKCM breakdown →