HLA-DQA2

Across TCGA pan-cancer cohorts, HLA-DQA2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HLA-DQA2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DQA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DQA2 is over-expressed in tumor, although a few such as LUSC and PAAD show the opposite, repressed pattern.

KIRC, LUSC, and PAAD are the cancer types where HLA-DQA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DQA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.530	<.001	11	view →
LUSC	All	All	−1.645	<.001	5	view →
PAAD	All	All	−2.042	.018	4	view →
THCA	Male	II,III,IV	+2.032	.022	4	view →
BRCA	All	All	+0.730	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HLA-DQA2–KIRC

Open the KIRC breakdown →