Across TCGA patient cohorts, HLA-DPB2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DPB2-associated genes across cancer lineages are RN7SL44P, RNU1-14P, and RNU4ATAC15P. Each is linked with HLA-DPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DPB2-to-partner and partner-to-HLA-DPB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPB2→partner) and Y-score (partner→HLA-DPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL44P →	+0.234	+5.031	.009	.009	3	1
UCEC	RNU1-14P →	+0.458	+5.242	.004	.007	3	1
UCEC	RNU4ATAC15P →	+0.458	+5.852	<.001	.003	3	1
UCEC	METTL7AP1 →	+0.107	+5.358	.007	.006	3	1
UCEC	HERC2P11 →	+0.158	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

HLA-DPB2 survival (RNA) · tumor vs normal (RNA) · all HLA-DPB2 data types