Q-omics provides the consensus-scored HERC2P11 profile across patient tissues and cancer cell-line models. HERC2P11 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in DLBC. Among the 18 cancer types available for tumor–normal comparison, HERC2P11 is differentially expressed in 3, with the highest sampling consensus in KIRC. Additionally, HERC2P11 RNA expression shows 4,695 significant pathway-activity associations, with the highest sampling consensus in BRCA. Together, these results highlight DLBC, KIRC, and BRCA as cancer lineages where HERC2P11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HERC2P11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HERC2P11 survival associations across molecular data types. HERC2P11 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HERC2P11 RNA expression–survival associations across cancer types. High HERC2P11 expression shows unfavorable associations in DLBC, READ, KICH, THCA, BLCA and CHOL. The DLBC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify DLBC as the clearest survival context for HERC2P11 RNA expression.
This table summarizes HERC2P11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for HERC2P11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HERC2P11 shows lower tumor expression in KIRC and KICH and higher tumor expression in LUSC. The KIRC box plot shows higher HERC2P11 RNA expression in normal versus tumor tissue (log2 FC = −0.016, t-test p = .007).
This table shows molecular features associated with HERC2P11 in patient tissues and cancer cell lines. In patient samples, HERC2P11 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set.
