HERC2P11

Across TCGA pan-cancer cohorts, HERC2P11 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated HERC2P11 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher HERC2P11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HERC2P11 expression acts as an unfavorable survival marker, although some lineages such as OV and SKCM show a favorable association.

DLBC, READ, and KICH are the cancer types where HERC2P11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	72	view →
READ	OS	Tertile	All	0.641	0.927	<.001	57	view →
KICH	DFS	Tertile	III,IV	0.025	0.773	<.001	36	view →
THCA	OS	Quartile	III,IV	0.884	0.988	.004	23	view →
UVM	DFS	Tertile	III,IV	0.202	0.598	.004	18	view →
BLCA	OS	Tertile	IV	0.141	0.573	.034	18	view →
CHOL	OS	Tertile	All	0.201	0.740	.003	18	view →
OV	DFS	Tertile	All	0.449	0.364	.030	18	view →
BRCA	DFS	Tertile	II,III,IV	0.896	0.949	.008	12	view →
KIRP	DFS	Tertile	All	0.833	0.928	.009	9	view →
SARC	OS	Tertile	All	0.646	0.875	.021	9	view →
SKCM	OS	Tertile	III,IV	0.745	0.351	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

HERC2P11–DLBC (DFS)

Open the DLBC breakdown →