HERC2P11

Across TCGA patient cohorts, HERC2P11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,695 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HERC2P11-associated GO terms across cancer lineages are RNA modification, DNA-templated transcription initiation, and tRNA metabolic process. Each is linked with HERC2P11 in more than 11 cancer types. Because this analysis shows association rather than direction, both HERC2P11-to-partner and partner-to-HERC2P11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA modification grouped by HERC2P11-low versus HERC2P11-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2P11→partner) and Y-score (partner→HERC2P11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	RNA modification →	+0.024	+0.094	<.001	<.001	3	12
SKCM	DNA-templated transcription initiation →	+0.024	+0.012	<.001	<.001	3	11
LAML	tRNA metabolic process →	+0.029	+0.068	<.001	<.001	3	11
LAML	tRNA modification →	+0.025	+0.083	<.001	.001	3	11
LAML	Macromolecule methylation →	+0.027	+0.094	<.001	.001	3	11
SKCM	Nucleotide-excision repair →	+0.021	+0.011	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,695 associations by consensus.

RNA modification by HERC2P11 expression — LAML

Explore this box plot interactively →