HLA-DPA2

Across TCGA patient cohorts, HLA-DPA2 RNA expression is significantly associated with the RNA expression of many other genes, with 5,606 significant associations in total. LAML shows the largest number of these associations.

The most reproducible HLA-DPA2-associated genes across cancer lineages are CIITA, HLA-DPB2, and HLA-DOA. Each is linked with HLA-DPA2 in more than 21 cancer types. Because this analysis shows association rather than direction, both HLA-DPA2-to-partner and partner-to-HLA-DPA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DPA2 versus CIITA in LAML, with a Pearson correlation of 0.57.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPA2→partner) and Y-score (partner→HLA-DPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CIITA →	+1.772	+0.985	<.001	<.001	3	22
SKCM	HLA-DPB2 →	+1.381	+0.059	<.001	<.001	3	22
LAML	HLA-DOA →	+2.063	+1.020	<.001	<.001	3	21
PAAD	TLR10 →	+1.206	+0.054	<.001	<.001	3	21
SKCM	HLA-DOB →	+1.533	+0.058	<.001	<.001	3	20
LAML	HLA-DRA →	+1.675	+1.019	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,606 associations by consensus.

HLA-DPA2 vs CIITA — LAML

Explore this scatter interactively →