HLA-DPA2

Across TCGA pan-cancer cohorts, HLA-DPA2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated HLA-DPA2 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DPA2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DPA2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CHOL show a favorable association.

SKCM, KIRC, and CHOL are the cancer types where HLA-DPA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	II,III,IV	0.463	0.270	.001	75	view →
KIRC	DFS	Tertile	IV	0.423	0.695	<.001	56	view →
CHOL	DFS	Tertile	All	0.892	0.243	.001	42	view →
THCA	OS	Tertile	III,IV	0.915	0.991	.001	42	view →
BLCA	OS	Tertile	III,IV	0.774	0.198	.019	36	view →
LIHC	DFS	Tertile	All	0.247	0.450	.005	27	view →
LUSC	DFS	Tertile	III,IV	0.705	0.286	.011	24	view →
UVM	DFS	Tertile	III,IV	0.079	0.674	.020	18	view →
CESC	OS	Tertile	All	0.913	0.767	.010	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
GBM	DFS	Tertile	All	0.173	0.320	.046	9	view →
READ	OS	Tertile	All	0.746	0.939	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HLA-DPA2–SKCM (OS)

Open the SKCM breakdown →