HLA-DPA2

Across TCGA pan-cancer cohorts, HLA-DPA2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HLA-DPA2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where HLA-DPA2 RNA is repressed in tumor relative to normal tissue. In most cancer types HLA-DPA2 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

LUSC, COAD, and THCA are the cancer types where HLA-DPA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DPA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.054	.007	3	view →
COAD	Male	II,III,IV	−0.032	.017	3	view →
THCA	All	All	−0.038	.012	2	view →
STAD	Female	III,IV	+0.229	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HLA-DPA2–LUSC

Open the LUSC breakdown →