HLA-DPA1

Across TCGA patient cohorts, HLA-DPA1 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HLA-DPA1-associated genes across cancer lineages are OR11G2, ARPP19P2, and RNU6-39P. Each is linked with HLA-DPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DPA1-to-partner and partner-to-HLA-DPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11G2 grouped by HLA-DPA1-low versus HLA-DPA1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPA1→partner) and Y-score (partner→HLA-DPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR11G2 →	+0.067	+5.788	<.001	.003	3	2
UCEC	ARPP19P2 →	+0.274	+4.939	.006	<.001	3	2
UCEC	RNU6-39P →	+0.611	+3.492	<.001	.003	3	2
UCEC	LARP7P1 →	+0.155	+3.771	.002	.003	3	2
SKCM	GUSBP16 →	+0.206	+3.649	.001	.008	3	2
SKCM	SPANXN3 →	+0.228	+3.711	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

OR11G2 by HLA-DPA1 expression — BLCA

Explore this box plot interactively →