HLA-DPA1

Across TCGA pan-cancer cohorts, HLA-DPA1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HLA-DPA1 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DPA1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DPA1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and UVM are the cancer types where HLA-DPA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.449	0.242	<.001	146	view →
KIRC	DFS	Quartile	II,III,IV	0.593	0.372	.004	76	view →
UVM	DFS	Median	All	0.378	0.828	<.001	61	view →
LGG	OS	Median	All	0.369	0.516	<.001	51	view →
HNSC	DFS	Quartile	III,IV	0.667	0.434	.001	49	view →
LUAD	DFS	Quartile	All	0.808	0.615	<.001	46	view →
CESC	OS	Tertile	III,IV	0.825	0.520	.016	44	view →
BRCA	DFS	Median	IV	0.925	0.438	.002	26	view →
LIHC	DFS	Median	III,IV	0.535	0.218	.008	19	view →
THYM	OS	Quartile	All	0.736	1.000	.014	15	view →
ACC	DFS	Quartile	All	0.817	0.453	.016	14	view →
UCS	DFS	Tertile	IV	0.942	0.323	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HLA-DPA1–SKCM (OS)

Open the SKCM breakdown →