HLA-DPA1

Across TCGA pan-cancer cohorts, HLA-DPA1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HLA-DPA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DPA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DPA1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where HLA-DPA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DPA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.278	<.001	12	view →
LUAD	Male	II,III,IV	−1.643	<.001	11	view →
LUSC	Male	II,III,IV	−2.568	<.001	8	view →
THCA	Male	IV	+3.130	.003	6	view →
UCEC	All	All	−1.508	<.001	4	view →
KICH	All	II,III,IV	−1.168	.015	3	view →
COAD	All	All	−0.572	.007	3	view →
ESCA	Female	All	+2.300	.019	2	view →
PAAD	All	All	−1.795	.043	2	view →
STAD	All	All	+0.969	.026	2	view →
CHOL	Female	All	+2.530	.006	1	view →
KIRP	All	All	+0.537	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HLA-DPA1–KIRC

Open the KIRC breakdown →