Across TCGA patient cohorts, HIGD1C mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIGD1C-associated genes across cancer lineages are ECM1P1, KRT8P47, and RN7SL248P. Each is linked with HIGD1C in more than 1 cancer types. Because this analysis shows association rather than direction, both HIGD1C-to-partner and partner-to-HIGD1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1C→partner) and Y-score (partner→HIGD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ECM1P1 →	+0.184	+3.354	<.001	.007	3	1
UCEC	KRT8P47 →	+0.053	+3.488	.001	.008	3	1
UCEC	RN7SL248P →	+0.139	+4.722	<.001	.004	3	1
UCEC	MIR7976 →	+0.614	+3.453	.001	.009	3	1
UCEC	MIR6747 →	+1.085	+3.942	<.001	.004	3	1
UCEC	PGBD4P2 →	+0.376	+3.561	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Exploration

HIGD1C survival (RNA) · tumor vs normal (RNA) · all HIGD1C data types