Across TCGA patient cohorts, HHLA3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHLA3-associated genes across cancer lineages are SNORD116-22, OR2D2, and MIR876. Each is linked with HHLA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHLA3-to-partner and partner-to-HHLA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA3→partner) and Y-score (partner→HHLA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD116-22 →	+0.788	+6.437	<.001	<.001	3	2
UCEC	OR2D2 →	+0.155	+4.633	.009	.004	3	1
HNSC	MIR876 →	+0.357	+7.954	<.001	.008	3	1
HNSC	OR4X7P →	+0.174	+7.954	<.001	.008	3	1
HNSC	MIR548AZ →	+0.318	+7.954	<.001	.008	3	1
COAD	MIR542 →	+0.278	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

HHLA3 survival (RNA) · tumor vs normal (RNA) · all HHLA3 data types