HHAT

Across TCGA patient cohorts, HHAT mutation is significantly associated with the RNA expression of many other genes, with 2,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHAT-associated genes across cancer lineages are SFPQP1, DDX3P3, and CPSF7. Each is linked with HHAT in more than 2 cancer types. Because this analysis shows association rather than direction, both HHAT-to-partner and partner-to-HHAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFPQP1 grouped by HHAT-low versus HHAT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHAT→partner) and Y-score (partner→HHAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SFPQP1 →	+0.046	+2.813	.001	.003	3	3
COAD	DDX3P3 →	+0.136	+2.771	.004	.008	3	3
UCEC	CPSF7 →	+0.398	+3.617	.002	.001	3	2
UCEC	CHD1 →	+0.459	+2.847	.008	.001	3	2
UCEC	WHAMM →	+0.875	+4.280	<.001	<.001	3	2
UCEC	PANK4 →	+0.375	+3.638	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,712 associations by consensus.

SFPQP1 by HHAT expression — SKCM

Explore this box plot interactively →