HHAT

Across TCGA pan-cancer cohorts, HHAT RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HHAT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HHAT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HHAT is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

KIRP, LIHC, and BRCA are the cancer types where HHAT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HHAT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.997	<.001	9	view →
LIHC	All	II,III,IV	+1.136	<.001	8	view →
BRCA	All	III,IV	+0.931	<.001	8	view →
THCA	Male	III,IV	−0.770	<.001	8	view →
COAD	Female	II,III,IV	−0.443	<.001	7	view →
KICH	All	All	−0.845	<.001	6	view →
UCEC	All	All	−0.676	.002	6	view →
CHOL	Male	All	+1.508	<.001	5	view →
READ	All	All	−0.631	<.001	5	view →
LUAD	All	All	+0.470	<.001	5	view →
KIRC	Male	II,III,IV	−0.390	.005	3	view →
ESCA	All	II,III,IV	+0.719	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HHAT–KIRP

Open the KIRP breakdown →