HEMK1

Across TCGA patient cohorts, HEMK1 mutation is significantly associated with the RNA expression of many other genes, with 667 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEMK1-associated genes across cancer lineages are RN7SL248P, MIR1266, and PRAMEF34P. Each is linked with HEMK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEMK1-to-partner and partner-to-HEMK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by HEMK1-low versus HEMK1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEMK1→partner) and Y-score (partner→HEMK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RN7SL248P →	+0.217	+4.290	<.001	.008	3	3
UCEC	MIR1266 →	+0.162	+2.964	.008	.002	3	2
LUSC	PRAMEF34P →	+0.044	+6.593	<.001	<.001	3	2
STAD	DEFB108F →	+0.684	+4.363	<.001	.007	3	2
STAD	MIRLET7A2 →	+0.585	+4.929	<.001	.002	3	2
STAD	RNU6-492P →	+0.488	+4.691	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 667 associations by consensus.

RN7SL248P by HEMK1 expression — STAD

Explore this box plot interactively →