HEMK1

Across TCGA pan-cancer cohorts, HEMK1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HEMK1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HEMK1 RNA is repressed in tumor relative to normal tissue. In most cancer types HEMK1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where HEMK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEMK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.584	<.001	10	view →
COAD	Male	III,IV	+0.471	<.001	10	view →
LIHC	Male	All	+0.625	<.001	9	view →
LUSC	All	II,III,IV	−0.527	<.001	6	view →
KICH	Female	All	−0.680	<.001	5	view →
HNSC	All	II,III,IV	−0.246	<.001	5	view →
CHOL	All	All	+0.670	.004	4	view →
UCEC	All	All	−0.441	<.001	4	view →
READ	Female	All	+0.390	.030	2	view →
KIRC	Male	All	−0.126	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HEMK1–THCA

Open the THCA breakdown →