HEMK1

Across TCGA pan-cancer cohorts, HEMK1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HEMK1 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher HEMK1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HEMK1 expression acts as an unfavorable survival marker, although some lineages such as READ and UVM show a favorable association.

READ, UVM, and PRAD are the cancer types where HEMK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.837	0.508	<.001	71	view →
UVM	OS	Quartile	All	0.955	0.554	<.001	67	view →
PRAD	DFS	Median	All	0.687	0.894	<.001	34	view →
KIRC	DFS	Median	IV	0.233	0.423	.010	32	view →
KICH	OS	Median	All	0.836	1.000	.015	32	view →
KIRP	DFS	Tertile	II,III,IV	0.898	0.641	.003	24	view →
THYM	OS	Median	All	1.000	0.687	.015	22	view →
BRCA	OS	Median	II,III,IV	0.937	0.888	.009	20	view →
LUAD	OS	Tertile	All	0.778	0.616	.003	18	view →
LGG	DFS	Quartile	All	0.798	0.911	.001	17	view →
ACC	DFS	Median	All	0.331	0.700	.018	16	view →
LUSC	DFS	Quartile	II,III,IV	0.486	0.675	.013	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HEMK1–READ (OS)

Open the READ breakdown →