HELLPAR

Across TCGA patient cohorts, HELLPAR RNA expression is significantly associated with the protein abundance of many other proteins, with 14,972 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HELLPAR-associated proteins across cancer lineages are SMC4, CPSF1, and ECT2_T359. Each is linked with HELLPAR in more than 6 cancer types. Because this analysis shows association rather than direction, both HELLPAR-to-partner and partner-to-HELLPAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELLPAR versus SMC4 in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLPAR→partner) and Y-score (partner→HELLPAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.876	+0.264	<.001	<.001	3	7
GBM	CPSF1 →	+0.291	+0.150	<.001	<.001	3	7
GBM	ECT2_T359 →	+1.246	+0.254	<.001	<.001	3	7
LUAD	TOP2A_S1106 →	+1.377	+0.432	<.001	<.001	3	7
GBM	NCL_S67 →	+0.915	+0.254	<.001	<.001	3	7
LUAD	RFC1 →	+0.340	+0.343	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,972 associations by consensus.

HELLPAR vs SMC4 — GBM

Explore this scatter interactively →