HELLPAR

Across TCGA pan-cancer cohorts, HELLPAR RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HELLPAR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HELLPAR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HELLPAR is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where HELLPAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HELLPAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.022	<.001	10	view →
THCA	All	II,III,IV	−0.007	<.001	9	view →
COAD	Female	II,III,IV	+0.017	<.001	8	view →
LUSC	Male	II,III,IV	+0.036	<.001	7	view →
STAD	Male	II,III,IV	+0.032	.001	5	view →
KIRC	Male	IV	+0.006	.003	4	view →
BLCA	All	All	+0.026	.026	2	view →
LUAD	All	All	+0.025	.012	2	view →
READ	All	All	+0.017	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HELLPAR–HNSC

Open the HNSC breakdown →