HDAC9

Across TCGA cell cohorts, HDAC9 mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC9-associated genes across cancer lineages are SULT2A1, NMD3, and OR3A1. Each is linked with HDAC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC9-to-partner and partner-to-HDAC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT2A1 grouped by HDAC9-low versus HDAC9-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC9→partner) and Y-score (partner→HDAC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SULT2A1 →	+0.110	+4.807	<.001	.006	3	2
LUNG_NSCLC_LUAD	NMD3 →	+0.490	+3.639	<.001	<.001	3	2
STOMACH	OR3A1 →	+0.070	+4.285	<.001	.007	3	2
LARGE_INTESTINE	ADPRM →	+0.574	+2.628	.001	.002	3	2
LARGE_INTESTINE	KCND3 →	+0.230	+2.197	.007	.004	3	2
LARGE_INTESTINE	CD300H →	+0.015	+2.540	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

SULT2A1 by HDAC9 expression — BLOOD_Myeloma

Explore this box plot interactively →