HDAC9

Across TCGA pan-cancer cohorts, HDAC9 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HDAC9’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HDAC9 RNA is repressed in tumor relative to normal tissue. In most cancer types HDAC9 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and KICH are the cancer types where HDAC9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HDAC9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.023	<.001	12	view →
HNSC	All	III,IV	+0.708	.001	7	view →
KICH	Female	II,III,IV	−1.070	<.001	6	view →
THCA	Female	All	+0.836	<.001	6	view →
READ	Female	All	−1.560	<.001	5	view →
LUAD	Male	II,III,IV	+0.899	.009	4	view →
CHOL	All	All	+1.070	<.001	3	view →
BLCA	Male	IV	−1.490	.003	2	view →
UCEC	All	All	−0.647	.038	2	view →
KIRP	All	All	+0.430	.008	2	view →
KIRC	Male	All	+0.255	.012	2	view →
LUSC	All	III,IV	−0.990	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HDAC9–COAD

Open the COAD breakdown →