HDAC9

Across TCGA pan-cancer cohorts, HDAC9 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HDAC9 data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher HDAC9 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC9 expression acts as an unfavorable survival marker, although some lineages such as ESCA and KIRC show a favorable association.

MESO, UVM, and THYM are the cancer types where HDAC9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.240	0.576	<.001	109	view →
UVM	DFS	Tertile	All	0.207	0.906	.002	46	view →
THYM	DFS	Quartile	All	0.613	0.931	.004	43	view →
ESCA	DFS	Quartile	All	0.635	0.363	.003	38	view →
KIRC	DFS	Median	All	0.903	0.841	.001	30	view →
LIHC	OS	Tertile	II,III,IV	0.644	0.227	.006	21	view →
BLCA	OS	Tertile	II,III,IV	0.574	0.705	.031	19	view →
SKCM	DFS	Quartile	All	0.688	0.531	.007	18	view →
LGG	OS	Median	All	0.759	0.860	.002	18	view →
LUAD	DFS	Quartile	III,IV	0.579	0.273	.007	18	view →
ACC	DFS	Median	All	0.638	0.308	.002	14	view →
LAML	DFS	Quartile	All	0.314	0.682	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HDAC9–MESO (OS)

Open the MESO breakdown →