HAPLN3

Across TCGA cell cohorts, HAPLN3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAPLN3-associated genes across cancer lineages are OR4E2, C1QBP, and GALR3. Each is linked with HAPLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAPLN3-to-partner and partner-to-HAPLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4E2 grouped by HAPLN3-low versus HAPLN3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN3→partner) and Y-score (partner→HAPLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4E2 →	+0.012	+2.637	.008	.007	3	2
LARGE_INTESTINE	C1QBP →	+0.822	+3.131	<.001	.008	3	1
LARGE_INTESTINE	GALR3 →	+0.078	+3.424	.008	.006	3	1
LARGE_INTESTINE	NRTN →	+1.090	+3.064	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	TFDP3 →	+0.013	+2.518	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR4E2 by HAPLN3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →