HAPLN3

Across TCGA pan-cancer cohorts, HAPLN3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HAPLN3 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HAPLN3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HAPLN3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, KIRP, and KIRC are the cancer types where HAPLN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.465	0.241	<.001	146	view →
KIRP	OS	Tertile	All	0.507	0.719	<.001	123	view →
KIRC	DFS	Tertile	All	0.514	0.687	<.001	86	view →
CESC	OS	Tertile	All	0.937	0.801	<.001	66	view →
LGG	OS	Median	All	0.727	0.887	<.001	47	view →
SCLC	DFS	Median	All	0.755	0.483	<.001	47	view →
LUAD	OS	Tertile	III,IV	0.718	0.383	.004	32	view →
UVM	OS	Median	III,IV	0.384	1.000	.020	18	view →
THYM	DFS	Quartile	II,III,IV	0.272	1.000	.002	16	view →
MESO	OS	Median	II,III,IV	0.293	0.513	.004	14	view →
PAAD	DFS	Quartile	All	0.143	0.405	.010	13	view →
ACC	OS	Quartile	II,III,IV	0.630	0.983	.021	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HAPLN3–SKCM (OS)

Open the SKCM breakdown →