HAPLN3

Across TCGA pan-cancer cohorts, HAPLN3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HAPLN3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HAPLN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HAPLN3 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where HAPLN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAPLN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+2.034	<.001	11	view →
KIRC	Male	IV	+1.734	<.001	11	view →
HNSC	Male	All	+1.107	<.001	10	view →
STAD	All	III,IV	+2.475	<.001	9	view →
LUAD	Female	II,III,IV	+1.307	<.001	9	view →
THCA	Male	II,III,IV	+1.285	<.001	8	view →
LIHC	All	II,III,IV	+0.895	<.001	8	view →
BRCA	Female	II,III,IV	−0.677	<.001	8	view →
READ	Male	All	+2.616	<.001	7	view →
LUSC	Male	All	+1.272	<.001	7	view →
UCEC	All	All	+1.737	<.001	6	view →
BLCA	Male	III,IV	+1.372	.005	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HAPLN3–COAD

Open the COAD breakdown →