HAND2

Across TCGA patient cohorts, HAND2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,291 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAND2-associated proteins across cancer lineages are SEPTIN11, SEPTIN7, and SGCB. Each is linked with HAND2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HAND2-to-partner and partner-to-HAND2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HAND2 versus SEPTIN11 in BRCA, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND2→partner) and Y-score (partner→HAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN11 →	+0.483	+0.515	<.001	.001	3	6
UCEC	SEPTIN7 →	+0.252	+1.133	<.001	<.001	3	6
HNSC	SGCB →	+0.812	+0.668	<.001	<.001	3	6
HNSC	SGCD →	+0.938	+0.644	<.001	<.001	3	6
COAD	SORBS1 →	+0.840	+1.041	<.001	<.001	3	6
COAD	SYNPO2 →	+0.871	+1.020	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,291 associations by consensus.

HAND2 vs SEPTIN11 — BRCA

Explore this scatter interactively →