HAND2

Across TCGA pan-cancer cohorts, HAND2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HAND2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HAND2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HAND2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and THCA show a favorable association.

UCEC, LGG, and BLCA are the cancer types where HAND2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.918	0.735	<.001	88	view →
LGG	DFS	Median	All	0.647	0.837	<.001	53	view →
BLCA	OS	Quartile	II,III,IV	0.529	0.724	.002	43	view →
ACC	OS	Median	II,III,IV	0.392	0.747	.003	32	view →
KIRP	DFS	Quartile	IV	0.176	0.657	.014	28	view →
THCA	DFS	Tertile	All	0.913	0.771	.018	22	view →
SKCM	OS	Quartile	III,IV	0.606	0.260	.020	16	view →
LUSC	DFS	Quartile	III,IV	0.222	0.930	.006	14	view →
OV	OS	Quartile	All	0.789	0.890	.024	12	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	12	view →
MESO	DFS	Quartile	III,IV	0.250	0.489	.022	12	view →
CESC	OS	Quartile	All	0.917	0.774	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HAND2–UCEC (DFS)

Open the UCEC breakdown →