HAND2 antisense RNA 1Genealiases: DEIN · NBLA00301 · UPH
Q-omics provides the consensus-scored HAND2-AS1 profile across patient tissues and cancer cell-line models. HAND2-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, HAND2-AS1 is differentially expressed in 15, with the highest sampling consensus in BLCA. Additionally, HAND2-AS1 RNA expression shows 14,551 significant protein co-abundance associations, with the highest sampling consensus in UCEC. Together, these results highlight KICH, BLCA, and UCEC as cancer lineages where HAND2-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HAND2-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HAND2-AS1 survival associations across molecular data types. HAND2-AS1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HAND2-AS1 RNA expression–survival associations across cancer types. High HAND2-AS1 expression shows unfavorable associations in KICH, KIRC, LGG, BLCA and ACC, but favorable associations in UCEC. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for HAND2-AS1 RNA expression.
This table summarizes HAND2-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for HAND2-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HAND2-AS1 shows lower tumor expression in BLCA, THCA, COAD, KIRC, LIHC and UCEC. The BLCA box plot shows higher HAND2-AS1 RNA expression in normal versus tumor tissue (log2 FC = −3.420, t-test p < 0.001).
This table shows molecular features associated with HAND2-AS1 in patient tissues and cancer cell lines. In patient samples, HAND2-AS1 shows the broadest associations at the RNA and protein expression levels, with UCEC recurring as the lineage with the largest associated feature set.
