HAND2-AS1

Across TCGA pan-cancer cohorts, HAND2-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HAND2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HAND2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HAND2-AS1 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and COAD are the cancer types where HAND2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAND2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.420	<.001	11	view →
THCA	Female	II,III,IV	−0.481	<.001	11	view →
COAD	Male	II,III,IV	−2.034	<.001	10	view →
KIRC	All	All	−0.012	<.001	9	view →
LIHC	Male	III,IV	−0.770	<.001	7	view →
UCEC	All	All	−2.938	<.001	6	view →
BRCA	All	All	−0.629	<.001	6	view →
READ	All	All	−3.065	<.001	5	view →
STAD	All	All	−1.891	<.001	5	view →
KICH	Male	All	−0.010	.014	5	view →
CHOL	All	II,III,IV	−0.580	.044	2	view →
PRAD	All	All	−0.135	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HAND2-AS1–BLCA

Open the BLCA breakdown →