HAND2-AS1

Across TCGA pan-cancer cohorts, HAND2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HAND2-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher HAND2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HAND2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.

KICH, KIRC, and UCEC are the cancer types where HAND2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.569	0.930	<.001	111	view →
KIRC	DFS	Tertile	III,IV	0.313	0.620	<.001	81	view →
UCEC	DFS	Quartile	II,III,IV	0.948	0.730	<.001	62	view →
LGG	DFS	Median	All	0.305	0.495	<.001	53	view →
BLCA	OS	Tertile	All	0.543	0.705	.002	30	view →
ACC	DFS	Quartile	II,III,IV	0.108	0.531	.001	29	view →
OV	OS	Quartile	All	0.763	0.882	.009	28	view →
LUSC	DFS	Median	III,IV	0.173	0.807	<.001	22	view →
BRCA	DFS	Median	III,IV	0.626	0.374	.011	12	view →
CESC	OS	Tertile	All	0.920	0.823	.020	10	view →
THCA	DFS	Median	All	0.928	0.863	.005	8	view →
CHOL	DFS	Tertile	All	0.787	0.159	.047	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HAND2-AS1–KICH (OS)

Open the KICH breakdown →