H3C7

Across TCGA patient cohorts, H3C7 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible H3C7-associated genes across cancer lineages are MIR5584, MIR4733, and RNA5SP377. Each is linked with H3C7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C7-to-partner and partner-to-H3C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5584 grouped by H3C7-low versus H3C7-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C7→partner) and Y-score (partner→H3C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR5584 →	+0.354	+4.733	<.001	.004	3	2
LUSC	MIR4733 →	+0.543	+3.862	<.001	.002	3	2
LUAD	RNA5SP377 →	+0.544	+4.888	<.001	.005	3	2
BLCA	CYB5AP5 →	+0.124	+7.640	<.001	.009	3	1
BLCA	MIR502 →	+0.488	+7.640	<.001	.009	3	1
STAD	LINC01688 →	+0.343	+4.929	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

MIR5584 by H3C7 expression — LUSC

Explore this box plot interactively →