H3C7

Across TCGA pan-cancer cohorts, H3C7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of H3C7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H3C7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3C7 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where H3C7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3C7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.465	<.001	8	view →
LUAD	All	II,III,IV	+0.264	.001	8	view →
KIRC	Male	II,III,IV	+0.111	<.001	8	view →
LUSC	Female	II,III,IV	+1.067	<.001	7	view →
UCEC	All	II,III,IV	+1.279	<.001	6	view →
BRCA	All	II,III,IV	+0.599	<.001	6	view →
COAD	Male	IV	−0.768	.004	5	view →
STAD	All	II,III,IV	+0.626	<.001	5	view →
BLCA	All	All	+1.227	.030	4	view →
LIHC	Male	All	+0.050	.006	3	view →
THCA	Female	II,III,IV	+0.218	.021	2	view →
KIRP	All	All	+0.054	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

H3C7–HNSC

Open the HNSC breakdown →