H3C7

Across TCGA pan-cancer cohorts, H3C7 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated H3C7 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H3C7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3C7 expression acts as an unfavorable survival marker, although some lineages such as BLCA and THYM show a favorable association.

HNSC, LGG, and BLCA are the cancer types where H3C7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.518	0.677	<.001	160	view →
LGG	DFS	Tertile	All	0.474	0.792	<.001	54	view →
BLCA	OS	Tertile	All	0.571	0.167	.003	48	view →
LIHC	OS	Tertile	II,III,IV	0.250	0.516	.001	45	view →
ACC	OS	Tertile	All	0.683	1.000	.001	38	view →
KIRP	DFS	Tertile	All	0.404	0.694	<.001	30	view →
ESCA	OS	Tertile	All	0.336	0.630	.001	26	view →
THYM	OS	Median	All	0.956	0.593	.007	16	view →
SCLC	OS	Tertile	II,III,IV	0.688	0.416	.021	14	view →
UCEC	DFS	Median	IV	0.665	0.277	.009	12	view →
PAAD	OS	Tertile	All	0.545	0.314	.033	11	view →
LUSC	OS	Tertile	All	0.732	0.612	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

H3C7–HNSC (DFS)

Open the HNSC breakdown →