Q-omics provides the consensus-scored H3C5P profile across patient tissues and cancer cell-line models. H3C5P expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, H3C5P is differentially expressed in 8, with the highest sampling consensus in BRCA. Additionally, H3C5P RNA expression shows 6,627 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight COAD, BRCA, and STAD as cancer lineages where H3C5P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for H3C5P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes H3C5P survival associations across molecular data types. H3C5P RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible H3C5P RNA expression–survival associations across cancer types. High H3C5P expression shows unfavorable associations in COAD, KIRP, SARC and READ, but favorable associations in BRCA and LUSC. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify COAD as the clearest survival context for H3C5P RNA expression.
This table summarizes H3C5P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for H3C5P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. H3C5P shows higher tumor expression in BRCA, BLCA, LUSC, HNSC, UCEC and STAD. The BRCA box plot shows higher H3C5P RNA expression in tumor versus normal tissue (log2 FC = +0.277, t-test p < 0.001).
This table shows molecular features associated with H3C5P in patient tissues and cancer cell lines. In patient samples, H3C5P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
