H3C5P

Across TCGA pan-cancer cohorts, H3C5P RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated H3C5P data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H3C5P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3C5P expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUSC show a favorable association.

COAD, BRCA, and KIRP are the cancer types where H3C5P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	IV	0.318	0.686	.002	54	view →
BRCA	OS	Median	IV	1.000	0.551	<.001	24	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
READ	DFS	Tertile	III,IV	0.216	0.660	<.001	18	view →
SARC	OS	Tertile	All	0.179	0.527	.002	18	view →
LUSC	DFS	Tertile	All	0.733	0.632	.025	17	view →
THYM	DFS	Tertile	II,III,IV	0.678	0.947	.004	16	view →
PRAD	DFS	Tertile	All	0.835	0.917	.008	12	view →
LGG	OS	Tertile	All	0.748	0.830	.017	6	view →
THCA	OS	Tertile	IV	0.559	0.873	.025	6	view →
KIRC	OS	Quartile	All	0.748	0.821	.034	3	view →
SKCM	DFS	Tertile	III,IV	0.452	0.213	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

H3C5P–COAD (OS)

Open the COAD breakdown →