H2AZ2

Across TCGA patient cohorts, H2AZ2 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AZ2-associated genes across cancer lineages are POM121L3P, IL21, and AQP7P2. Each is linked with H2AZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AZ2-to-partner and partner-to-H2AZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121L3P grouped by H2AZ2-low versus H2AZ2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AZ2→partner) and Y-score (partner→H2AZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	POM121L3P →	+0.035	+5.038	.002	.009	3	1
UCEC	IL21 →	+0.172	+2.763	.003	.009	3	1
UCEC	AQP7P2 →	+0.186	+2.747	<.001	.009	3	1
UCEC	RNA5SP405 →	+0.442	+3.997	<.001	.009	3	1
UCEC	RNU4-58P →	+0.307	+3.396	.001	.006	3	1
UCEC	RNU1-57P →	+0.347	+4.885	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

POM121L3P by H2AZ2 expression — BLCA

Explore this box plot interactively →