POM121 transmembrane nucleoporin like 3, pseudogeneGenealiases: POM121L3 · dJ831C21.3
Q-omics provides the consensus-scored POM121L3P profile across patient tissues and cancer cell-line models. POM121L3P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, POM121L3P is differentially expressed in 3, with the highest sampling consensus in THCA. Additionally, POM121L3P RNA expression shows 6,494 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KICH, THCA, and STAD as cancer lineages where POM121L3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for POM121L3P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes POM121L3P survival associations across molecular data types. POM121L3P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible POM121L3P RNA expression–survival associations across cancer types. High POM121L3P expression shows unfavorable associations in KICH, ACC and SKCM, but favorable associations in ESCA, HNSC and KIRP. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for POM121L3P RNA expression.
This table summarizes POM121L3P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for POM121L3P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. POM121L3P shows lower tumor expression in THCA and KIRP and higher tumor expression in HNSC. The THCA box plot shows higher POM121L3P RNA expression in normal versus tumor tissue (log2 FC = −0.050, t-test p < 0.001).
This table shows molecular features associated with POM121L3P in patient tissues and cancer cell lines. In patient samples, POM121L3P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
