H2AZ2

Across TCGA pan-cancer cohorts, H2AZ2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated H2AZ2 data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher H2AZ2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AZ2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LAML show a favorable association.

MESO, ACC, and UVM are the cancer types where H2AZ2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.263	0.505	<.001	99	view →
ACC	DFS	Median	All	0.233	0.674	<.001	83	view →
UVM	DFS	Median	III,IV	0.264	0.799	.002	68	view →
KIRC	OS	Tertile	All	0.719	0.491	<.001	58	view →
LIHC	DFS	Median	All	0.454	0.628	<.001	42	view →
LGG	OS	Median	All	0.757	0.868	<.001	31	view →
LAML	DFS	Median	All	0.499	0.205	<.001	30	view →
READ	DFS	Tertile	IV	0.190	0.703	.001	17	view →
KICH	DFS	Quartile	All	0.690	1.000	.013	15	view →
DLBC	OS	Median	All	1.000	0.600	.020	14	view →
THYM	OS	Median	All	0.965	0.738	.005	13	view →
CESC	OS	Median	IV	0.097	0.545	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

H2AZ2–MESO (OS)

Open the MESO breakdown →