H2AC17

Across TCGA patient cohorts, H2AC17 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AC17-associated genes across cancer lineages are PSKH2, RNU4-84P, and HIGD1AP2. Each is linked with H2AC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC17-to-partner and partner-to-H2AC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSKH2 grouped by H2AC17-low versus H2AC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC17→partner) and Y-score (partner→H2AC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSKH2 →	+0.087	+4.969	.002	.002	3	2
UCEC	RNU4-84P →	+0.411	+4.694	<.001	.007	3	2
UCEC	HIGD1AP2 →	+0.367	+5.453	.003	.002	3	2
DLBC	SEPTIN7P5 →	+0.161	+4.874	<.001	.008	3	1
DLBC	MAGEB18 →	+0.088	+4.874	<.001	.008	3	1
DLBC	RNU6-1112P →	+0.448	+4.874	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

PSKH2 by H2AC17 expression — UCEC

Explore this box plot interactively →