Q-omics provides the consensus-scored H2AB2 profile across patient tissues and cancer cell-line models. H2AB2 expression is associated with patient survival in 4 of 34 cancer types, with the highest sampling consensus in LUSC. Additionally, H2AB2 RNA expression shows 1,058 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LUSC, and STAD as cancer lineages where H2AB2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes H2AB2 survival associations across molecular data types. H2AB2 RNA expression shows survival associations in the most cancer types (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

H2AB2 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	4	LUSC (90)	view →

This table ranks reproducible H2AB2 RNA expression–survival associations across cancer types. High H2AB2 expression shows unfavorable associations in LUSC, LGG, BLCA and ESCA. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for H2AB2 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.113	0.664	<.001	90	view →
LGG	OS	Tertile	All	0.006	0.896	<.001	36	view →
BLCA	DFS	Tertile	All	0.218	0.616	.032	18	view →
ESCA	DFS	Tertile	II,III,IV	0.268	0.510	.011	18	view →

Pink = unfavorable, green = favorable. all 4 lineages →

H2AB2-LUSC (DFS)

Kaplan–Meier survival curve for H2AB2 RNA expression in LUSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with H2AB2 in patient tissues and cancer cell lines. In patient samples, H2AB2 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, H2AB2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in CNS and BLOOD_Lymphoma.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	1,058	STAD (1010)	view →
RNA	538	STAD (227)	view →

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	3,494	BONE (1088)	view →
CRISPR	1,373	CNS (124)	view →
▼Protein (mass-spec)
RNA	182	BLOOD_Lymphoma (182)	view →
Function (RNA)	116	BLOOD_Lymphoma (116)	view →