H2AB2

Across TCGA pan-cancer cohorts, H2AB2 RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated H2AB2 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher H2AB2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2AB2 expression acts as an unfavorable survival marker.

LUSC, LGG, and BLCA are the cancer types where H2AB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.113	0.664	<.001	90	view →
LGG	OS	Tertile	All	0.006	0.896	<.001	36	view →
BLCA	DFS	Tertile	All	0.218	0.616	.032	18	view →
ESCA	DFS	Tertile	II,III,IV	0.268	0.510	.011	18	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H2AB2–LUSC (DFS)

Open the LUSC breakdown →